Grupo Desportivo Fabril is a Portuguese sports club established as Grupo Desportivo CUF do Barreiro (commonly known as CUF Barreiro), with CUF standing for the company Companhia União Fabril. A multisports club best known for its football section, it was founded as a works team in the city of Barreiro, District of Setúbal, on 27 January 1937. CUF Barreiro's greatest achievement was a third place in the 1964–65 Portuguese Liga season. The club's football home ground is the Complexo Desportivo Alfredo da Silva, which was inaugurated in June 1965 and named after Alfredo da Silva, an entrepreneur who was the founder of CUF.

Besides football, Fabril's futsal team has reached top-flight twice in their history, participating in the I Divisão in the 2012–13 and 2016–17 seasons. In the 2012–13 season, Fabril reached the 5th round of the Taça de Portugal.